• DysphoriaGirl
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    6 days ago

    I am dumb so it’s probably wrong but…

    I kind of have a concept or idea for how we could make puberty blockers for trans girls that won’t cause infertility…

    Which would be good for indecisive trans youth but also a huge OpticsWin for us…

    Where should I post that???

    • pleasantaftertastes
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      6 days ago

      those already exist, and I take one. GrNH agonists. As hormones that target receptors develop, there will probably be ones that allow the gonads to still function. kinda hard tho, since it’s the same hormones that drive all those processes. But yeah, SERMs and Agonists.

      • DysphoriaGirl
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        6 days ago

        Oh.

        I personally thought one could design a selevtive Androgen Receptor Blocker, similar to how Bicalutamide functions, but that doesn’t cross the blood testis barrier which would cause testosterone to still be produces but not affect any part of the body except the ball and sperm production

          • DysphoriaGirl
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            6 days ago

            How so… there is am AR-blocker who doesn’t cross the blood brain bariere very well as far as I’ve heard… so it could be possible… one could idk make that selevtive AR Blocker very bound to blood serum and difficult to diffuse by making its surface area very big and idk… you’re the smart one…but idk… it was just an idea…

            • pleasantaftertastes
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              6 days ago

              Oh no, this is actually quite brilliant. If we were to go about it, that probably how it would be done. If you leave the testes and brain alone, the body will continue to produce high levels of Testosterone. To block the natural Testosterone in the skin and voice box, your drug would have to be extremely strong. If the natural T levels are high, you would need a very high dose of the blocker to keep the receptors occupied. At high doses, even the most powerful drugs eventually start leaking across those barriers. Realistically? Absolutely possible. WOULD cost billions to develop, though.

              • DysphoriaGirl
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                6 days ago

                Dosage is what I worried about as well… you would need a lot of a possibly very expensive blood to do in the tissue locally what you could more easily do in the system globally… also yeah…who’s gonna fund that lmaoooooi

                  • DysphoriaGirl
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                    6 days ago

                    We need propaganda… we need so much propaganda and drive them to develop this stuff for us… we need to target them and blast then with propaganda and then plant the solution in front of them and wait till they simply mentally break and give in and finally finance it… 😶🥴🤫

      • pleasantaftertastes
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        6 days ago

        I’m pretty sure my fertility is fine, actually. never really understood the appeal of fertility though… like why personally want to breed more? there are plenty children who already need a parent.

        • DysphoriaGirl
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          6 days ago

          How? If you take high enough Estrogen, sooner or later your body will downregulate the production of GnRH which will then cause a drop of T in the testis and no more FSH and LH and thereby no more spermatogenisis…right?

            • DysphoriaGirl
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              6 days ago

              Hmm… interesting… can you teach me some of this stuff so I understand it better… I wanna get it right

      • pleasantaftertastes
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        6 days ago

        still, absurdly difficult due to ethical concerns and the not so precise nature of hormones.

        • DysphoriaGirl
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          6 days ago

          I think it would be cute if I could be your little lab assistant… I’d run and tell you crazy ideas while you teach me some stuff on why it’s a good idea but has some difficulties and sometimes you’re disturbed and tell me that we need to get it past the ethics board too hehe… and we generally have fun and get really close and science mog some moids while also looking stunning and hug and cheer each other on with regards to our academic and personal life’s and ugh…

          God, what’s wrong with me… why do I keep having such fantasies and daydreams about idk… being happy and ugh… I’m so sorry…

          • pleasantaftertastes
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            6 days ago

            that is super cute. you could absolutely be my lab partner. one day we can meet for tea and discuss the landscape of our fields.