• DysphoriaGirl
    2·
    11 days ago

    Oh.

    I personally thought one could design a selevtive Androgen Receptor Blocker, similar to how Bicalutamide functions, but that doesn’t cross the blood testis barrier which would cause testosterone to still be produces but not affect any part of the body except the ball and sperm production

      • DysphoriaGirl
        1·
        11 days ago

        How so… there is am AR-blocker who doesn’t cross the blood brain bariere very well as far as I’ve heard… so it could be possible… one could idk make that selevtive AR Blocker very bound to blood serum and difficult to diffuse by making its surface area very big and idk… you’re the smart one…but idk… it was just an idea…

        • pleasantaftertastes
          2·
          11 days ago

          Oh no, this is actually quite brilliant. If we were to go about it, that probably how it would be done. If you leave the testes and brain alone, the body will continue to produce high levels of Testosterone. To block the natural Testosterone in the skin and voice box, your drug would have to be extremely strong. If the natural T levels are high, you would need a very high dose of the blocker to keep the receptors occupied. At high doses, even the most powerful drugs eventually start leaking across those barriers. Realistically? Absolutely possible. WOULD cost billions to develop, though.

          • DysphoriaGirl
            2·
            11 days ago

            Dosage is what I worried about as well… you would need a lot of a possibly very expensive blood to do in the tissue locally what you could more easily do in the system globally… also yeah…who’s gonna fund that lmaoooooi

              • DysphoriaGirl
                3·
                11 days ago

                We need propaganda… we need so much propaganda and drive them to develop this stuff for us… we need to target them and blast then with propaganda and then plant the solution in front of them and wait till they simply mentally break and give in and finally finance it… 😶🥴🤫