It seems that for some people, only stronger substances like ethinylestradiol or diethylstilbestrol will work. I have been on ethinylestradiol for 1.5 years and I’m a happy twinkhon now. They are way riskier than bioidentical estrogens but also far more potent. When I become a passoid I will make a report on it in hopes that more trannies will take the leap of faith. Hell, I read about a cis woman who had to use estrogen for cattle in order to be healthy. Nothing else worked for her.